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Phenotypes Associated with This Genotype
Genotype
MGI:5750141
Allelic
Composition
Tg(MAPT*V337M)1Gds/0
Genetic
Background
B6J.Cg-Tg(MAPT*V337M)1Gds
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MAPT*V337M)1Gds mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• by 15-18 months of age, mutants spend more time the open arms of the elevated plus maze than controls indicating decreased anxiety
• mice treated with cycloserine, a NMDAR co-agonist, spend less time in the open arms compared to untreated mice
• older mice exhibit repetitive grooming that increases as mice age
• repetitive grooming becomes so severe enough to cause facial lesions by about 15-18 months of age, with full penetrance by 28 months
• however, mice exhibit normal social behavior, motor coordination, and spatial learning and memory
• injection with cycloserine significantly decreases grooming behavior
• mice develop nest building deficits by 3-5 months of age
• mice treated with cycloserine show improved nest building behavior

nervous system
• smaller postsynaptic densities at excitatory synapses onto spines
• however, mice show normal density and size of dendritic spines of medium spiny neurons in the ventral striatum and do not exhibit neuron loss in the ventral striatum or the insular cortex
• mice show a decrease in excitatory transmission and impaired network activity in the ventral striatum at 14 months of age
• mutants show no difference between the frequency of sEPSC and mEPSC events unlike wild-type mice which show more frequent sEPSC than mEPSC, suggesting less action potential-dependent input onto medium spiny neurons
• mEPSC and sEPSC amplitudes are decreased, indicating decreased postsynaptic AMPAR function
• NMDAR-dependent fEPSPs are decreased in the ventral striatum
• mEPSC and sEPSC amplitudes are decreased, indicating decreased postsynaptic AMPAR function
• however, mEPSC frequency is unchanged

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
frontotemporal dementia DOID:9255 OMIM:600274
OMIM:600795
J:218742


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory