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Phenotypes Associated with This Genotype
Genotype
MGI:5749858
Allelic
Composition
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?
Pdzrn3tm1.1Ysa/Pdzrn3tm1.1Ysa
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (1098 available)
Pdzrn3tm1.1Ysa mutation (1 available); any Pdzrn3 mutation (51 available)
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• embryos exposed to tamoxifen
• delayed vascularization of the superficial retinal vascular plexus at 5-12 days of age
• vessels are unstable
• endothelial cell proliferation is increased
• reduced vascular density and decreased number of branch points in the superficial retinal vascular plexus
• capillary network massively reduced in the deep capillary plexus
• capillary orientation in the superficial plexus relative to the deep plexus is disrupted

cardiovascular system
• delayed vascularization of the superficial retinal vascular plexus at 5-12 days of age
• vessels are unstable
• endothelial cell proliferation is increased
• reduced vascular density and decreased number of branch points in the superficial retinal vascular plexus
• capillary network massively reduced in the deep capillary plexus
• capillary orientation in the superficial plexus relative to the deep plexus is disrupted


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory