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Phenotypes Associated with This Genotype
Genotype
MGI:5749790
Allelic
Composition
Tg(Camk2a-MAPT)601Ymot/0
Genetic
Background
involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• 16 month old mice do worse in memory retention (probe) test of the Morris water maze
• however, mice show no differences in motor function or activity
• 16 month old mice take longer to learn the task in the acquisition test of the Morris water maze indicating impaired place learning
• 16 month old mice show decreased spontaneous alternation in the Y-maze indicating impaired working memory
• 16 month old mice spend more time in the open arms of the elevated plus maze test than controls, indicating impaired anxiety

cellular
• living old mice show decreased glucose metabolism in the nucleus accumbens

nervous system
• 16 month old mice show loss of synapses and dendritic spines in the nucleus accumbens
• mice exhibit axonal dilatations primarily in cortical layers V and VI of the prefrontal cortex with aging, as well as in the sensorimotor cortex and the orbitofrontal cortex
• however, mice do not exhibit formation of tau aggregates or neurofibrillary tangles and show no signs of neuronal loss, astrogliosis, or microglial proliferation
• 16 month old mice show loss of dendritic spines in the nucleus accumbens
• 16 month old mice show loss of synapses in the nucleus accumbens

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
frontotemporal dementia DOID:9255 OMIM:600274
J:172762


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory