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Phenotypes Associated with This Genotype
Genotype
MGI:5749252
Allelic
Composition
Lamb3tm1.1Hosc/Lamb3tm1.1Hosc
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lamb3tm1.1Hosc mutation (0 available); any Lamb3 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice die at birth or within 24 hours of birth
• no pups survive the first 3 days of life

integument
• skin shows absence of the alpha3 and beta3 chains of laminin-332, whereas collagen VII is not diminished
• irregular clefting at the dermo-epidermal junction
• erosions of the abdominal skin, paws or the tail tip
• skin erosions affect 5-15% of the total body surface
• blistering of the abdominal skin, paws or the tail tip
• blisters usually develop within 2 days of life, although a few mice have blisters at first examination

growth/size/body
• pups affected with blisters lose up to 13% of body weight

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
junctional epidermolysis bullosa Herlitz type DOID:0060737 OMIM:226700
J:218616


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory