Phenotypes Associated with This Genotype

Genotype
MGI:5707796

• Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Adipoq-cre)1Evdr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased pancreatic beta cell apoptosis ( J:228009 )

• increase in apoptosis of beta cells

endocrine/exocrine glands

increased pancreatic beta cell apoptosis ( J:228009 )

• increase in apoptosis of beta cells

abnormal pancreatic islet morphology ( J:228009 )

• structures of pancreatic islets are disrupted, with increased apoptosis of beta cells after onset of diabetes and more severe at later stages

decreased insulin secretion ( J:228009 )

• insulin secretion declines after 8 weeks of age

growth/size/body

decreased body weight ( J:228009 )

• lower body weight after onset of diabetes

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:228009 )

N • mice exhibit normal lipid profiles up to the age of 14 weeks, including total cholesterol, low-density lipoprotein, high-density lipoprotein, triglyceride and free fatty acid

decreased insulin secretion ( J:228009 )

• insulin secretion declines after 8 weeks of age

hyperglycemia ( J:228009 )

• age-dependent increase in glucose levels

• level of hyperglycemia seen with glucose tolerance test is prolonged compared to controls