Phenotypes Associated with This Genotype

Genotype
MGI:5707772

• Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami; Tg(Pdgfra-cre)1Clc/0
• Genetic Background: B6.Cg-Senp1^tm1Wami Tg(Pdgfra-cre)1Clc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

hyperglycemia ( J:228009 )

• age-dependent increase in glucose levels, with an early onset of diabetes at 6 weeks of age

• increase in glucose levels is seen with or without fasting

growth/size/body

decreased body weight ( J:228009 )

• lower body weight after onset of diabetes

endocrine/exocrine glands

abnormal pancreatic islet cell apoptosis ( J:228009 )

• increase in apoptosis of beta cells

abnormal pancreatic islet morphology ( J:228009 )

• structures of pancreatic islets are disrupted, with increased apoptosis of beta cells after onset of diabetes and more severe at later stages

abnormal pancreatic beta cell physiology ( J:228009 )

• increase in apoptosis of beta cells after onset of diabetes and more severe at later stages

cellular

abnormal pancreatic islet cell apoptosis ( J:228009 )

• increase in apoptosis of beta cells