Phenotypes Associated with This Genotype

Genotype
MGI:5707654

• Allelic Composition: Mirc32^tm1.1Jtm/Mirc32^tm1.1Jtm; Tg(Myh11-cre,-EGFP)2Mik/?
• Genetic Background: B6.Cg-Mirc32^tm1.1Jtm Tg(Myh11-cre,-EGFP)2Mik

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:214382 )

• lamina propia myofibroblasts within the ulcers of DSS treated (+ 2 days recovery) mice are abnormal

abnormal large intestine crypts of Lieberkuhn morphology ( J:214382 )

• DSS treated (+ 2 days recovery) mice exhibit impaired epithelial regeneration

intestinal ulcer ( J:214382 )

• observed in DSS treated (+ 2 days recovery) mice

abnormal colon morphology ( J:214382 )

• colons from DSS treated (+ 2 days recovery) mice remain hemorrhagic and necrotic

• however, phenotype is less severe than in Mirc32^tm1.2Jtm mice

colonic necrosis ( J:214382 )

• observed in DSS treated (+ 2 days recovery) mice

impaired intestine regeneration ( J:214382 )

• DSS treated (+ 2 days recovery) mice exhibit impaired epithelial regeneration

• pH3+ cells are reduced in number

increased susceptibility to induced colitis ( J:214382 )

• DSS treated (+ 2 days recovery) mice exhibit impaired epithelial regeneration

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:214382 )

• DSS treated (+ 2 days recovery) mice exhibit impaired epithelial regeneration

immune system

increased susceptibility to induced colitis ( J:214382 )

• DSS treated (+ 2 days recovery) mice exhibit impaired epithelial regeneration