Phenotypes Associated with This Genotype

Genotype
MGI:5707501

• Allelic Composition: Helz2^tm1Tesa/Helz2^tm1Tesa
• Genetic Background: B6.Cg-Helz2^tm1Tesa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:218127 )

N • normal food intake on a normal diet

N • normal locomotor activity on a normal diet

growth/size/body

growth/size/body region phenotype ( J:218127 )

N • body weight gain is normal on a normal diet

slow postnatal weight gain ( J:218127 )

• weight gain is less than for controls on a high fat diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:218127 )

N • normal fasting blood glucose on a normal diet

N • insulin levels are normal on a normal diet

N • leptin levels normal on a normal diet

N • normal adiponectin levels on a normal diet

increased circulating leptin level ( J:218127 )

• sustained hyperleptinemia on a high fat diet

abnormal gas homeostasis ( J:218127 )

increased oxygen consumption ( J:218127 )

• relative to controls on a high fat diet

decreased respiratory quotient ( J:218127 )

• relative to controls on a high fat diet

abnormal glucose homeostasis ( J:218127 )

decreased fasting circulating glucose level ( J:218127 )

• on a high fat diet

decreased circulating insulin level ( J:218127 )

• on a high fat diet

abnormal lipid level ( J:218127 )

• less fat deposition than controls on a high fat diet

decreased liver triglyceride level ( J:218127 )

• triglyceride levels are reduced in the liver on a high fat diet

liver/biliary system

decreased liver triglyceride level ( J:218127 )

• triglyceride levels are reduced in the liver on a high fat diet

abnormal liver size ( J:218127 )

• liver enlargement is reduced relative to controls on a high fat diet

hepatic steatosis ( J:218127 )

• ameliorated relative to controls on a high fat diet