Phenotypes Associated with This Genotype

Genotype
MGI:5705535

• Allelic Composition: Tg(Ggt1-tTA)#Agoc/0; Tg(tetO/CMV-Hgf)#Agoc/0
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to kidney reperfusion injury ( J:130310 )

• mice exhibit decreased renal damage induced by ischemia/reperfusion, showing reduced tubular damage with fewer obstructing casts, reduced levels of plasma creatinine and BUN levels compared to controls and increased survival rate after 48 hours after ischemia/reperfusion

• mice exhibit increased kidney tubular cell proliferation and decreased apoptosis 48 hours after ischemia/reperfusion

• however, mice treated with doxycycline to turn off expression exhibit similar renal damage to ischemia/reperfusion as controls

• under normal physiologic conditions, kidney weight and morphology appears normal at 4 months of age and circulating markers of kidney function, BUN, and plasma creatinine concentrations are normal

renal/urinary system

decreased susceptibility to kidney reperfusion injury ( J:130310 )

• mice exhibit decreased renal damage induced by ischemia/reperfusion, showing reduced tubular damage with fewer obstructing casts, reduced levels of plasma creatinine and BUN levels compared to controls and increased survival rate after 48 hours after ischemia/reperfusion

• mice exhibit increased kidney tubular cell proliferation and decreased apoptosis 48 hours after ischemia/reperfusion

• however, mice treated with doxycycline to turn off expression exhibit similar renal damage to ischemia/reperfusion as controls

• under normal physiologic conditions, kidney weight and morphology appears normal at 4 months of age and circulating markers of kidney function, BUN, and plasma creatinine concentrations are normal