Phenotypes Associated with This Genotype

Genotype
MGI:5705500

• Allelic Composition: Kdr^tm2.1Jrt/Kdr^tm2.1Jrt; Tg(Pax6-cre,GFP)2Pgr/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:217533 )

• ragged and caved edges in vascular fronts with persistent hyaloid vessels and slight delay in radial growth in the retina

• at P6, mice show abundant vertical branching into the neuroblastic layers unlike in control mice

• misdirected vascular growth

• at P9, deep and intermediate plexuses have already formed unlike in control mice

• at P28, mice exhibit increased vessel branching in intermediate and deep plexuses compared with control mice

• mice exhibit decreased regenerative angiogenesis that does not progress to deep layers with abnormal vessels growing into intra-capillary spaces compared with control mice

• however, no additional angiogenesis is observed

vision/eye

vision/eye phenotype ( J:217533 )

N • retinas exhibit normal neuronal thickness, morphology, proliferation and survival and vertical sprouts extend between normal ganglion cells

abnormal retina vasculature morphology ( J:217533 )

• ragged and caved edges in vascular fronts with persistent hyaloid vessels and slight delay in radial growth in the retina

• at P6, mice show abundant vertical branching into the neuroblastic layers unlike in control mice

• misdirected vascular growth

• at P9, deep and intermediate plexuses have already formed unlike in control mice

• at P28, mice exhibit increased vessel branching in intermediate and deep plexuses compared with control mice

• mice exhibit decreased regenerative angiogenesis that does not progress to deep layers with abnormal vessels growing into intra-capillary spaces compared with control mice

• however, no additional angiogenesis is observed

persistence of hyaloid vascular system ( J:217533 )