Analysis Tools
behavior/neurological
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• mice are hyperactive in the open field
• however, mice exhibit normal anxiety in the elevated plus maze, normal novel object recognition, spatial learning and contextual fear conditioning
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• mice display stereotypic behavior in the marble burying task, burying more marbles and at a faster rate
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• mice show deficits in social interaction, with mice showing no preference for the stranger mouse versus an inanimate object as seen in wild-type mice
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nervous system
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• mice exhibit higher levels of protein synthesis in the brain
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