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Phenotypes Associated with This Genotype
Genotype
MGI:5702952
Allelic
Composition
Mecp2tm6.1Bird/Y
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm6.1Bird mutation (1 available); any Mecp2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• motor coordination and behavioral phenotypes are less severe when compared to phenotypes observed in mice carrying Mecptm4.1Brd and Mecptm5.1Brd
• onset of phenotypes is gradual as compared to mice carrying Mecptm4.1Brd and Mecptm5.1Brd
• decrease in latency to fall in 3-day accelerated rotarod-learning paradigm by day 3 as compared to controls
• increased time in open arms of elevated plus maze as compared to controls, but not as compared to Mecptm3.1Brd (WT-GFP) control
• increase in latency to fall in hanging wire test as compared to controls

growth/size/body

mortality/aging
• median survival is 42 weeks

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:227401


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory