Analysis Tools
cardiovascular system
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• hypoxia-induced pulmonary hypertension is ameliorated in mutants
• hypoxia-induced increases in right ventricular systolic pressure, right ventricular end-diastolic pressure, peak rates of right ventricular pressure development and relaxation, right ventricle hypertrophy, pulmonary vascular remodeling, the number of CD45+ inflammatory cells in the hypoxic pulmonary artery, and pulmonary vascular cell proliferation are suppressed in mutants compared to controls
• however, mice show no differences in heart rate, systemic blood pressure, or left ventricular hemodynamic parameters before or after chronic hypoxia, no differences in pulmonary vasculature and right ventricular systolic pressure under normoxic conditions, and no differences in hemoglobin levels and platelet counts following long-term exposure to hypoxia compared to controls
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• in vitro, aortic vascular smooth muscle migration in response to fetal bovine serum is decreased
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• in vitro, aortic vascular smooth muscle cell proliferation in response to fetal bovine serum is decreased
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immune system
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• levels of inflammatory cytokines like interferon-gamma and TNF-alpha secreted by vascular smooth muscle cells are reduced under both normoxic and hypoxic conditions
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muscle
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• in vitro, aortic vascular smooth muscle migration in response to fetal bovine serum is decreased
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• in vitro, aortic vascular smooth muscle cell proliferation in response to fetal bovine serum is decreased
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cellular
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• in vitro, aortic vascular smooth muscle cell proliferation in response to fetal bovine serum is decreased
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