Phenotypes for Cd160 Rag1 MGI:5702315 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Cd160^tm1Yxf/Cd160^tm1Yxf Rag1^tm1Mom/Rag1^tm1Mom
Genetic Background	B6.Cg-Rag1^tm1Mom Cd160^tm1Yxf

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd160^tm1Yxf mutation (1 available); any Cd160 mutation (16 available)
Rag1^tm1Mom mutation (56 available); any Rag1 mutation (132 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interferon-gamma secretion ( J:222131 )

• reduced interferon gamma production from splenocytes stimulated by Nk1.1 cross-linking

neoplasm

increased tumor growth/size ( J:222131 )

• increased tumor volume/weight following inoculation with NK-dependent B16 or RMA-S (no MHC class I surface expression) tumor cells as compared to homozygous Rag^tm1Mom control

• tumors generated by inoculation with RMA (normal MHC class I) cells have weights similar to Rag^tm1Mom controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24