Phenotypes Associated with This Genotype

Genotype
MGI:5701639

• Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal macrophage physiology ( J:221901 )

• phagocytic capacity of bone marrow-derived macrophages is exacerbated compared to wild-type macrophages, with macrophages showing increased clearance of E. coli

• treatment with cytochalasin B blocks the increased activity of E. coli engulfment by bone marrow-derived macrophages

homeostasis/metabolism

abnormal circulating cytokine level ( J:221901 )

• mice challenged with LPS show an increase in inflammatory cytokines in the serum

immune system

abnormal macrophage physiology ( J:221901 )

• phagocytic capacity of bone marrow-derived macrophages is exacerbated compared to wild-type macrophages, with macrophages showing increased clearance of E. coli

• treatment with cytochalasin B blocks the increased activity of E. coli engulfment by bone marrow-derived macrophages

abnormal circulating cytokine level ( J:221901 )

• mice challenged with LPS show an increase in inflammatory cytokines in the serum

increased tumor necrosis factor secretion ( J:221901 )

• bone marrow-derived macrophages challenged with PAMP:LPS, CpG oligodeoxynucleotide (CpG ODN) or zymosan depleted of TLR-stimulating properties show enhanced TNF-alpha production

• heterozygous mice orally treated with chronic LPS stimulation exhibit serum TNF-alpha levels similar to those of untreated homozygotes

increased susceptibility to bacterial infection ( J:221901 )

• mice infected with high doses of E. coli are more sensitive to septic shock compared to wild-type mice