Phenotypes for Icam1 Vcam1 MGI:5701418 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Icam1^tm1Jcgr/Icam1^tm1Jcgr Vcam1^tm1Dmil/Vcam1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icam1^tm1Jcgr mutation (3 available); any Icam1 mutation (24 available)
Vcam1^tm1Dmil mutation (0 available); any Vcam1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cell chemotaxis ( J:227109 )

• reduced recruitment of leukocytes into peritoneal cavity as compared to wild-type, but not homozygote, following IP challenge with ovalbumin

• numbers of monocytes, macrophages and lymphocytes recovered from the peritoneal cavity are reduced, but not neutrophils or eosinophils

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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