Phenotypes Associated with This Genotype

Genotype
MGI:5700532

• Allelic Composition: Tg(PGK1-FTL*)#Sle/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

oxidative stress ( J:227451 )

• mice show a higher level of carbonylated proteins in the brain at 6 months and show a 2-fold increase at 12 months, indicating oxidative damage

behavior/neurological

behavior/neurological phenotype ( J:226967 )

N • Background Sensitivity: mice on the FVB/N background behave similarly to wild-type mice in behavioral tests and no locomotor differences are seen up to 2 years of age unlike mice on a congenic C57BL/6J background which have impaired coordination

abnormal behavioral response to xenobiotic ( J:226967 )

• mice treated with the herbicides Paraquat and Maneb to induce neurodegeneration show an increase in locomotor, rearing and exploratory activity compared to controls

homeostasis/metabolism

abnormal iron homeostasis ( J:227451 )

• ferritin iron/ferritin protein ratio is lower in the brain, indicating a reduced capacity of the ferritin to incorporate iron

increased brain iron level ( J:227451 )

• mice show increased iron and ferritin accumulation in the brain at 12 and 22 months of age

• Background Sensitivity: iron and ferritin accumulation is higher on the FVB/N background than on a congenic C57BL/6J background

nervous system

increased brain iron level ( J:227451 )

• mice show increased iron and ferritin accumulation in the brain at 12 and 22 months of age

• Background Sensitivity: iron and ferritin accumulation is higher on the FVB/N background than on a congenic C57BL/6J background

neuronal intranuclear inclusions ( J:227451 )

• mice show the presence of aggregates of human ferritin inside neurons at 18 and 22 months of age