Phenotypes Associated with This Genotype

Genotype
MGI:5699563

• Allelic Composition: Ntrk1^tm1.1Azmo/Ntrk1^tm1.1Azmo
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Peripheral, but not central innervation is drastically reduced in Ntrk1^tm1.1Azmo/Ntrk1^tm1.1Azmo mice

nervous system

nervous system phenotype ( J:210892 )

N • dorsal root ganglia appear normal

N • spinal cord sensory innervation is normal

abnormal skin sensory neuron innervation pattern ( J:210892 )

• sensory nerve targeting to skin is defective, disorganized and drastically reduced

abnormal neurite morphology ( J:210892 )

• neurite outgrowth from dorsal root ganglion explants are of lower density and tortuous in appearance

decreased sensory neuron number ( J:210892 )

• sensory neuron in adult dorsal root ganglia are very modestly reduced in number

• drastic decrease in peptidergic nociceptive fibers in glabrous skin of adults

integument

abnormal skin sensory neuron innervation pattern ( J:210892 )

• sensory nerve targeting to skin is defective, disorganized and drastically reduced

behavior/neurological

behavior/neurological phenotype ( J:210892 )

N • locomotor and anxiety behavior is normal

abnormal thermosensation ( J:210892 )

• decreased response to a hot plate at 52C

• greater tolerance for cold (14C)

abnormal chemical nociception ( J:210892 )

• reduced response in formalin test for continuous pain

abnormal nociception after inflammation ( J:210892 )

• reduced hyperalgesic response to complete Freund's adjuvant