Phenotypes Associated with This Genotype

Genotype
MGI:5699561

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Glg1^{Gt(RST092)Byg}/Glg1⁺
• Genetic Background: B6J.129P2-Apoe^tm1Unc Glg1^{Gt(RST092)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:226586 )

N • mice exhibit no significant differences in right and left ventricular chamber thickness or in myocardial collagen deposition relative to Apoe^tm1Unc homozygotes

atherosclerotic lesions ( J:226586 )

• after 9 weeks on a Western diet, mice exhibit atherosclerotic lesions with increased collagen deposition and fewer macrophages per mm2 of lesion relative to lesions from Apoe^tm1Unc homozygotes, as shown by collagen-specific (Sirius Red) and macrophage-specific (CD68) staining of aortic valves

• altered lesion composition suggests increased plaque stability; however, no differences in lesion area and thickness or in accumulation of smooth muscle cells are observed relative to Apoe^tm1Unc homozygotes

immune system

impaired macrophage chemotaxis ( J:226586 )

• after 9 weeks on a Western diet, mice exhibit a significantly reduced macrophage content in atherosclerotic lesions relative to Apoe^tm1Unc homozygotes

decreased macrophage cell number ( J:226586 )

• mice exhibit a significantly reduced macrophage content and CD68 expression in liver tissue relative to Apoe^tm1Unc homozygotes

hematopoietic system

impaired macrophage chemotaxis ( J:226586 )

• after 9 weeks on a Western diet, mice exhibit a significantly reduced macrophage content in atherosclerotic lesions relative to Apoe^tm1Unc homozygotes

decreased macrophage cell number ( J:226586 )

• mice exhibit a significantly reduced macrophage content and CD68 expression in liver tissue relative to Apoe^tm1Unc homozygotes

homeostasis/metabolism

increased collagen level ( J:226586 )

• after 9 weeks on a Western diet, mice exhibit significantly increased collagen deposition in atherosclerotic lesions relative to Apoe^tm1Unc homozygotes

cellular

impaired macrophage chemotaxis ( J:226586 )

• after 9 weeks on a Western diet, mice exhibit a significantly reduced macrophage content in atherosclerotic lesions relative to Apoe^tm1Unc homozygotes