Phenotypes Associated with This Genotype

Genotype
MGI:5699417

• Allelic Composition: Sod3^tm1Svp/Sod3^tm1Svp
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal pulmonary artery morphology ( J:285340 )

• increased medial wall and adventitial remodeling in response to hypoxia induced pulmonary hypertension

heart right ventricle hypertrophy ( J:285340 )

• in response to hypoxia induced pulmonary hypertension

increased right ventricle systolic pressure ( J:285340 )

• in response to hypoxia induced pulmonary hypertension

increased response of heart to induced stress ( J:285340 )

• elevated right ventricular systolic pressure in response to hypoxia induced pulmonary hypertension

• right ventricular hypertrophy in response to hypoxia induced pulmonary hypertension

muscle

heart right ventricle hypertrophy ( J:285340 )

• in response to hypoxia induced pulmonary hypertension

homeostasis/metabolism

increased response of heart to induced stress ( J:285340 )

• elevated right ventricular systolic pressure in response to hypoxia induced pulmonary hypertension

• right ventricular hypertrophy in response to hypoxia induced pulmonary hypertension

immune system

decreased susceptibility to endotoxin shock ( J:285340 )

• fewer bronchoalveolar lavage fluid (BALF) total cells, neutrophils and pro-inflammatory cytokines after lipopolysaccharide (LPS) exposure through inhalation

• total BALF protein level after lipopolysaccharide (LPS) exposure through inhalation

growth/size/body

heart right ventricle hypertrophy ( J:285340 )

• in response to hypoxia induced pulmonary hypertension