Analysis Tools
behavior/neurological
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• mice develop motor paralysis/motor neuron disease with later disease onset and slower progression than in transgenic mice with only the H46R mutation; disease onset is on average 705 days in females
• however, mice show normal performance on the rotarod up to 42 weeks of age and many survive past 1000 days
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nervous system
astrocytosis
(
J:221350
)
|
• a slight increase in activation of astrocytes is seen in the spinal cords of 40 week old mice
|
microgliosis
(
J:221350
)
|
• a slight increase in activation of microglia is seen in the spinal cords of 40 week old mice
|
hematopoietic system
microgliosis
(
J:221350
)
|
• a slight increase in activation of microglia is seen in the spinal cords of 40 week old mice
|
immune system
microgliosis
(
J:221350
)
|
• a slight increase in activation of microglia is seen in the spinal cords of 40 week old mice
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growth/size/body
| N |
• mice do not exhibit a notable weight loss up to 42 weeks of age
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cellular
astrocytosis
(
J:221350
)
|
• a slight increase in activation of astrocytes is seen in the spinal cords of 40 week old mice
|
microgliosis
(
J:221350
)
|
• a slight increase in activation of microglia is seen in the spinal cords of 40 week old mice
|
