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Phenotypes Associated with This Genotype
Genotype
MGI:5698394
Allelic
Composition		 Cftrtm1Unc/Cftrtm1Unc
Tg(FABPCFTR)1Jaw/0
Tg(Scgb1a1-Scnn1b)6608Bouc/0
Genetic
Background		 involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cftrtm1Unc mutation (8 available); any Cftr mutation (98 available)
Tg(FABPCFTR)1Jaw mutation (1 available)
Tg(Scgb1a1-Scnn1b)6608Bouc mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:191673 )
• survival is reduced by about 70% at P3

respiratory system
respiratory system inflammation ( J:191673 )
• airway inflammation levels are similar to single Tg(Scgb1a1-Scnn1b)6608Bouc mice
pulmonary epithelial necrosis ( J:191673 )
• airway necrosis is increased compared to single Tg(Scgb1a1-Scnn1b)6608Bouc mice
abnormal mucociliary clearance ( J:191673 )
• intraluminal mucus obstruction is increased compared to single Tg(Scgb1a1-Scnn1b)6608Bouc mice

immune system
respiratory system inflammation ( J:191673 )
• airway inflammation levels are similar to single Tg(Scgb1a1-Scnn1b)6608Bouc mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory