Phenotypes Associated with This Genotype

Genotype
MGI:5698391

• Allelic Composition: Tg(Scgb1a1-Scnn1b)6608Bouc/0
• Genetic Background: C.Cg-Tg(Scgb1a1-Scnn1b)6608Bouc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:191673 )

• Background Sensitivity: 81% of mice die due to airway mucus obstruction, indicating increased mortality on the BALB/c background compared to a mixed C3H and C57BL/6 or C57BL/6 congenic background

respiratory system

pulmonary epithelial necrosis ( J:191673 )

• Background Sensitivity: the number of necrotic cells in the airway epithelium is increased, with a greater increase on the BALB/c background compared to the C57BL/6 background in neonates

• extent of airway necrosis in 3 week old mice does not differ on the BALB/c or C57BL/6 background

abnormal respiratory mucosa goblet cell morphology ( J:191673 )

• extent of goblet cell metaplasia is similar on the C57BL/6 and the BALB/c background

abnormal respiratory system physiology ( J:191673 )

• increase in basal and amiloride-sensitive short-circuit current in neonatal tracheal tissue, indicating increased airway absorption of Na⁺

• cAMP-induced short-circuit current is increased in neonatal tracheal tissue

• Background Sensitivity: bumetanide-sensitive and CFTR_inh-172-sensitive short-circuit current is decreased in tracheal tissues of neonates on the BALB/c background compared to on the C57BL/6 background, indicating that basal chloride secretion is lower on the BALB/c background

respiratory system inflammation ( J:191673 )

• airway inflammation, with similar levels on the C57BL/6 or BALB/c backgrounds

emphysema ( J:191673 )

• extent of emphysema formation in 3 week old mice does not differ on the C57BL/6 or BALB/c background

abnormal mucociliary clearance ( J:191673 )

• Background Sensitivity: mucus obstruction is seen in the trachea but not in the intrapulmonary airways of neonates, with mucus content increased to a greater extent on the BALB/c background compared to the C57BL/6 background

• extent of airway mucous obstruction in 3 week old mice does not differ on the BALB/c or C57BL/6 background

immune system

respiratory system inflammation ( J:191673 )

• airway inflammation, with similar levels on the C57BL/6 or BALB/c backgrounds