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Phenotypes Associated with This Genotype
Genotype
MGI:5698063
Allelic
Composition
Kcnj10tm1Lst/Kcnj10tm1Lst
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnj10tm1Lst mutation (1 available); any Kcnj10 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
• mice show virtually no growth after P4

homeostasis/metabolism
• in the neonatal period, all mice exhibit lower urinary creatinine concentration
• urinary sodium concentration is elevated, indicating renal salt loss
• reduction in calcium excretion

renal/urinary system
• in the neonatal period, all mice exhibit lower urinary creatinine concentration
• urinary sodium concentration is elevated, indicating renal salt loss
• reduction in calcium excretion
• mice exhibit tubulopathy
• polyuria in all mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
EAST syndrome DOID:0060484 OMIM:612780
J:226598


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory