Phenotypes Associated with This Genotype

Genotype
MGI:5698050

• Allelic Composition: Evc2^tm2.1Mis/Evc2^tm2.1Mis; Tg(Mpz-cre)94Imeg/0
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

short lower incisors ( J:226455 )

• lower incisors showed slightly shorter length and relatively normal radio density

short upper incisors ( J:226455 )

• upper incisors were shorter than those in control littermates

abnormal tooth development ( J:226455 )

• at E18.5, pre-ameloblasts located in the posterior area of normal upper incisor are less differentiated with fully extended nuclei within ameloblasts

• at E18.5 deposition of extracellular matrix proteins surrounding ameloblasts is reduced

abnormal ameloblast morphology ( J:226455 )

• at E18.5 revealed that ameloblasts in mutant mice did not polarize appropriately when compared to those with control littermates

skeleton

short lower incisors ( J:226455 )

• lower incisors showed slightly shorter length and relatively normal radio density

short upper incisors ( J:226455 )

• upper incisors were shorter than those in control littermates

abnormal tooth development ( J:226455 )

• at E18.5, pre-ameloblasts located in the posterior area of normal upper incisor are less differentiated with fully extended nuclei within ameloblasts

• at E18.5 deposition of extracellular matrix proteins surrounding ameloblasts is reduced

abnormal ameloblast morphology ( J:226455 )

• at E18.5 revealed that ameloblasts in mutant mice did not polarize appropriately when compared to those with control littermates

growth/size/body

short lower incisors ( J:226455 )

• lower incisors showed slightly shorter length and relatively normal radio density

short upper incisors ( J:226455 )

• upper incisors were shorter than those in control littermates

abnormal tooth development ( J:226455 )

• at E18.5, pre-ameloblasts located in the posterior area of normal upper incisor are less differentiated with fully extended nuclei within ameloblasts

• at E18.5 deposition of extracellular matrix proteins surrounding ameloblasts is reduced

abnormal ameloblast morphology ( J:226455 )

• at E18.5 revealed that ameloblasts in mutant mice did not polarize appropriately when compared to those with control littermates

mortality/aging

mortality/aging ( J:226455 )

N • did not notice lethality in the neural crest-specific mutant mice during the period of observation (up to 6 months)