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Phenotypes Associated with This Genotype
Genotype
MGI:5697946
Allelic
Composition
Tnnt1tm1.2Jin/Tnnt1tm1.2Jin
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnnt1tm1.2Jin mutation (0 available); any Tnnt1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• hypertrophic growth of type II fast fibers and atrophy of type I slow fibers in soleus muscle
• soleus muscle type I slow fibers are small-sized
• approximate 40% decrease in the cross-sectional area of type I slow fibers
• atrophy of type I slow fibers in soleus muscle
• the cross-sectional area of fast type II muscle fibers from soleus muscles is increased by about 76%
• soleus muscle type I slow fibers are characterized by centrally nucleated fibers
• loss of type I slow fibers in the adult soleus and diaphragm muscles resulting in a switch to nearly pure fast fiber muscle
• in vivo length of soleus muscles is shorter
• twitch force normalized to cross-sectional area is decreased by about 25% in soleus muscle
• the optimal length of soleus muscles at which maximum twitch force is achieved in ex vivo contractility experiments is shorter
• soleus muscle shows decreased fatigue tolerance with impaired recovery
• the time for maximum force development during twitch contraction is shorter in soleus muscles, however contractile velocity is normal
• force-frequency analysis shows that at low stimulation frequency of 40 Hz, force production is soleus muscles is lower than in controls
• relaxation velocity of twitch and tetanic contractions are accelerated in soleus muscles

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
nemaline myopathy 5 DOID:0110936 OMIM:605355
J:219907


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory