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Phenotypes Associated with This Genotype
Genotype
MGI:5697918
Allelic
Composition
Flot1tm1.1Arte/Flot1tm1.1Arte
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flot1tm1.1Arte mutation (0 available); any Flot1 mutation (18 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• no clear difference in Abeta cleavage product amounts from APP relative to controls as determined by Western blot
• clearly less Abeta as determined by ELISA
• 76% reduction in area covered by plaques

nervous system
• no clear difference in Abeta cleavage product amounts from APP relative to controls as determined by Western blot
• clearly less Abeta as determined by ELISA
• 76% reduction in area covered by plaques


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory