Phenotypes Associated with This Genotype

Genotype
MGI:5697649

• Allelic Composition: Insc^tm1.2Cayo/Insc^tm1.2Cayo
• Genetic Background: B6.129(SJL)-Insc^tm1.2Cayo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal cochlear hair cell morphology ( J:214064 )

• hair cells of homozygotes have smaller apical surfaces and bundles that appear more flattened than normal at birth, and there is a reduction of the bare zone surface by 4 days of age

• despite the abnormalities in subcellular domain features, hair cell orientation in the tissue is normal

abnormal cochlear hair cell stereociliary bundle morphology ( J:214064 )

• in a small subset of hair cells stereocillia form two sub-bundles

nervous system

abnormal cochlear hair cell morphology ( J:214064 )

• hair cells of homozygotes have smaller apical surfaces and bundles that appear more flattened than normal at birth, and there is a reduction of the bare zone surface by 4 days of age

• despite the abnormalities in subcellular domain features, hair cell orientation in the tissue is normal

abnormal cochlear hair cell stereociliary bundle morphology ( J:214064 )

• in a small subset of hair cells stereocillia form two sub-bundles