Phenotypes Associated with This Genotype

Genotype
MGI:5697374

• Allelic Composition: Hdc^tm1Nagy/Hdc⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:220412 )

N • mice show normal baseline locomotion, exploratory rearing, and center occupancy in the open field, and no evident spontaneous motor stereotypies

abnormal behavioral response to amphetamine ( J:220412 )

• locomotor activation is attenuated after amphetamine administration

• mutants show increased motor stereotypies compared to controls after a high dose of amphetamine administration, consisting of repetitive focused sniffing and orofacial movements

• pretreatment with haloperidol, a dopamine D2 receptor antagonist, eliminates the stereotypies induced by amphetamine

• mice infused with histamine intracerebroventricularly immediately before administration of amphetamine show delayed and reduced amplitude of stereotypy

nervous system

abnormal substantia nigra morphology ( J:220412 )

• mice exhibit higher dopamine D2 and D3 receptor density in the substantia nigra than controls

abnormal striatum morphology ( J:220412 )

• mice exhibit a reduction in dopamine D2 and D3 receptor density in the dorsal striatum

decreased prepulse inhibition ( J:220412 )

• mice exhibit a deficit in auditory PPI at three prepulse intensities

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Gilles de la Tourette syndrome		DOID:11119	OMIM:137580	J:220412