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Phenotypes Associated with This Genotype
Genotype
MGI:5697374
Allelic
Composition
Hdctm1Nagy/Hdc+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdctm1Nagy mutation (0 available); any Hdc mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice show normal baseline locomotion, exploratory rearing, and center occupancy in the open field, and no evident spontaneous motor stereotypies
• locomotor activation is attenuated after amphetamine administration
• mutants show increased motor stereotypies compared to controls after a high dose of amphetamine administration, consisting of repetitive focused sniffing and orofacial movements
• pretreatment with haloperidol, a dopamine D2 receptor antagonist, eliminates the stereotypies induced by amphetamine
• mice infused with histamine intracerebroventricularly immediately before administration of amphetamine show delayed and reduced amplitude of stereotypy

nervous system
• mice exhibit higher dopamine D2 and D3 receptor density in the substantia nigra than controls
• mice exhibit a reduction in dopamine D2 and D3 receptor density in the dorsal striatum
• mice exhibit a deficit in auditory PPI at three prepulse intensities

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Gilles de la Tourette syndrome DOID:11119 OMIM:137580
J:220412


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory