Phenotypes Associated with This Genotype

Genotype
MGI:5695594

• Allelic Composition: Rgcc^{tm1(KOMP)Wtsi}/Rgcc^{tm1(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:218659 )

• some still births observed at E16.5

• ratio of births diverges from a Mendelian ratio: +/+=26%, +/-=49%, -/-=15%, stillbirths=10%

growth/size/body

decreased birth weight ( J:218659 )

• 27% lighter at birth than control littermates

decreased body weight ( J:218659 )

• body weight difference remains stable until 4 weeks of age (22% lighter than wild-type controls)

• size difference is less dramatic after 5 weeks

• however, growth index is similar to that in wild-type controls during the first 4 weeks

decreased fetal size ( J:218659 )

• E16.5 embryos are smaller than wild-type

decreased fetal weight ( J:218659 )

• E16.5 fetal weight is 80% of wild-type controls

fetal growth retardation ( J:218659 )

• fetal growth restriction due to impaired placental angiogenesis

embryo

abnormal placental labyrinth vasculature morphology ( J:218659 )

• fewer fetal capillaries with bigger vessel lumens in the midline of the placenta labyrinth

abnormal vitelline vasculature morphology ( J:218659 )

• E11.5 yolk sacs display fewer and smaller blood vessels than wild-type yolk sacs

decreased placental labyrinth size ( J:218659 )

• center but not the periphery of the placental labyrinth is significantly reduced in size

small placenta ( J:218659 )

• E16.5 placentas are smaller than wild-type

decreased placenta weight ( J:218659 )

• E16.5 placenta weight is 82% of wild-type controls

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:218659 )

• fewer fetal capillaries with bigger vessel lumens in the midline of the placenta labyrinth

abnormal vitelline vasculature morphology ( J:218659 )

• E11.5 yolk sacs display fewer and smaller blood vessels than wild-type yolk sacs