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Phenotypes Associated with This Genotype
Genotype
MGI:5695524
Allelic
Composition
Terctm1Rdp/Terctm1Rdp
Genetic
Background
B6J.Cg-Terctm1Rdp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terctm1Rdp mutation (4 available); any Terc mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• increase in bone marrow fat content in aged mice
• 41.7% and 84.9% decrease in femur bone volume at 3 months of age and in aged mice, respectively
• 27.1% and 49.3% increase in cortical porosity in young and aged mice, respectively
• 4% and 28.2% decrease in cortical bone area in young and aged mice, respectively
• decrease in cortical thickness in both young and aged mice
• young femurs show a more rod-like trabecular structure
• increase in trabecular separation
• accelerated bone aging characteristic features of human senile osteoporosis
• osteoid significantly decreases with age
• bone shows mechanical alterations including an increase in structure model index, a decrease in anisotropy and a decrease in the moment of inertia
• mineralized surface, mineral apposition rate, and bone formation rate dramatically decline with age

adipose tissue
• increase in bone marrow fat content in aged mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
osteoporosis DOID:11476 OMIM:166710
J:213181


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory