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Phenotypes Associated with This Genotype
Genotype
MGI:5695369
Allelic
Composition		 Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Tg(TcraTcrb)425Cbn/?
Genetic
Background		 involves: C57BL/6 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp1tm1.1Wz mutation (0 available); any Rasgrp1 mutation (57 available)
Tg(TcraTcrb)425Cbn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive T cell differentiation ( J:225109 )
• only 2% CD4+ thymocytes compared to 26% in heterozygous controls

hematopoietic system
abnormal CD4-positive T cell differentiation ( J:225109 )
• only 2% CD4+ thymocytes compared to 26% in heterozygous controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory