Phenotypes Associated with This Genotype

Genotype
MGI:5695298

• Allelic Composition: Prkcb^tilc/Prkcb^tilc
• Genetic Background: involves: C57BL/6JSfdAnu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:221236 )

N • IgG1 and IgG total levels are comparable to controls

N • normal T cell dependent antibody responses

decreased B cell proliferation ( J:221236 )

• spleen cells show reduced entry of B cells into the cell cycle after B cell receptor stimulation

decreased B-1a cell number ( J:221236 )

• near absence of B-1a lymphocytes in the peritoneal cavity of homozygotes

abnormal humoral immune response ( J:221236 )

• significantly reduced antibody to TI-2 antigens

decreased IgG3 level ( J:221236 )

• basal levels decreased 75%

decreased IgM level ( J:221236 )

• 75% reduction in IgM levels in un-immunized homozygous mice

hematopoietic system

decreased B cell proliferation ( J:221236 )

• spleen cells show reduced entry of B cells into the cell cycle after B cell receptor stimulation

decreased B-1a cell number ( J:221236 )

• near absence of B-1a lymphocytes in the peritoneal cavity of homozygotes

decreased IgG3 level ( J:221236 )

• basal levels decreased 75%

decreased IgM level ( J:221236 )

• 75% reduction in IgM levels in un-immunized homozygous mice

cellular

decreased B cell proliferation ( J:221236 )

• spleen cells show reduced entry of B cells into the cell cycle after B cell receptor stimulation