Phenotypes Associated with This Genotype

Genotype
MGI:5694455

• Allelic Composition: Fen1^tm2.1Bhsh/Fen1⁺
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

aneuploidy ( J:218627 )

• average % of near-tetraploid aneuploidy in heterozygous mutant MEFs cells is 9.6% relative to 6.6% for wild-type MEFs

decreased fibroblast proliferation ( J:218627 )

• under normal culture conditions, heterozygous mutant MEFs show mild-to-moderate defects in cell growth relative to wild-type MEFs

• upon treatment with camptothecin (CPT), the number of heterozygous mutant live cells is increased by only 1.7% per day, whereas the number of wild-type cells is increased by 10% per day

spontaneous chromosome breakage ( J:218627 )

• heterozygous mutant MEFs exhibit significantly more spontaneous chromosome breaks (1.0%) than wild-type MEFs (0.6%)