Phenotypes Associated with This Genotype

Genotype
MGI:5693975

• Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal reflex ( J:225567 )

• truncal twisting during tail suspension

• sustained forepaw straining during tail suspension

limb grasping ( J:225567 )

• forelimb clasping during tail suspension

tremors ( J:225567 )

impaired balance ( J:225567 )

• balance beam crossing using forepaws and dragging hind paws

• increased number of footslips on balance beam as compared to control

impaired coordination ( J:225567 )

• balance beam crossing using forepaws and dragging hind paws

• increased number of footslips on balance beam as compared to control

decreased grip strength ( J:225567 )

• impaired ability to remain suspended in horizontal grid hang test (decreased latency to fall)

weakness ( J:225567 )

hunched posture ( J:225567 )

• hunched posture on balance beam

growth/size/body

decreased body weight ( J:225567 )

• reduced body weight beginning at P7 as compared to controls

mortality/aging

premature death ( J:225567 )

• 47.37% survival rate

• most of loss occurs by 30 days of age

nervous system

gliosis ( J:225567 )

• regions of gliosis found in deep cerebellar nuclei, cortex, thalamus, red nucleus and facial motor nucleus

abnormal cerebellum deep nucleus morphology ( J:225567 )

• reduced numbers of deep cerebellar nuclei

abnormal neuron morphology ( J:225567 )

• ubiquitin accumulation found in deep cerebellar nuclei, cortex, thalamus, red nucleus and facial motor nucleus

neurodegeneration ( J:225567 )

vision/eye

delayed eyelid opening ( J:225567 )

cellular

gliosis ( J:225567 )

• regions of gliosis found in deep cerebellar nuclei, cortex, thalamus, red nucleus and facial motor nucleus