Phenotypes Associated with This Genotype

Genotype
MGI:5693950

• Allelic Composition: Zbtb20^tm1Stoy/Zbtb20^tm1Stoy
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:220958 )

• all remaining mice die between 5 and 24 days of age

• most dead pups with milk in stomach and air accumulation in the intestine

• average life span is 16 days

perinatal lethality, incomplete penetrance ( J:220958 )

• normal Mendelian ratios during embryonic development

• homozygotes present in reduced numbers at birth (18% rather than 25%)

growth/size/body

decreased body size ( J:220958 )

• starting at 6 days of age

decreased body length ( J:220958 )

• arrested axial growth

nervous system

abnormal Ammon gyrus morphology ( J:220958 )

• reduced

abnormal hippocampus CA1 region morphology ( J:220958 )

• typical pyramidal cell layer not identified

• some pyramidal cells identified in CA1 until day 10

abnormal dentate gyrus morphology ( J:220958 )

• misshaped

decreased dentate gyrus size ( J:220958 )

small hippocampus ( J:220958 )

• significant reduction of hippocampus

abnormal subiculum morphology ( J:220958 )

• more compact

behavior/neurological

hyperactivity ( J:220958 )

vision/eye

eye hemorrhage ( J:220958 )

• "clotty" eyes

integument

disheveled coat ( J:220958 )

• ragged coat

cardiovascular system

eye hemorrhage ( J:220958 )

• "clotty" eyes