Phenotypes Associated with This Genotype

Genotype
MGI:5693761

• Allelic Composition: \Tg(Camk2a-tTA)1Mmay/?; \Tg(tetO-DRD2)2-5Kndl/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:106982 )

• mice exhibit a behavioral flexibility deficit in bowl reversal test

• mice exhibit increased latency to choose between two odors in single discrimination reversal trials

abnormal spatial reference memory ( J:106982 )

• memory impairment is observed in the eight-arm radial win-shift delayed non-match to sample (DNMTS) maze

• impaired acquisition of task is observed in the DNMTS T-maze; controls reach preset criterion more quickly than transgenic mice

• performance deficit in the T maze exists in the presence or absence of doxycycline

homeostasis/metabolism

increased dopamine level ( J:106982 )

• increase in dopamine levels

• decrease in dopamine turnover as determined by DOPAC:DA and HVA:DA ratios

abnormal metabolism ( J:106982 )

• decrease in basal metabolic activity in the caudate putamen as measured by glucose uptake

• increase in activity in primary motor and somatosensory cortices