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Phenotypes Associated with This Genotype
Genotype
MGI:5693400
Allelic
Composition		 Bmi1tm1Sgon/Bmi1tm1Sgon
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/?
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmi1tm1Sgon mutation (0 available); any Bmi1 mutation (31 available)
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (7 available); any Gt(ROSA)26Sor mutation (1095 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:221849 )
N
• tamoxifen induction of cre at 4 weeks of age
premature death ( J:221849 )
• mice die at 28-32 weeks of age

hematopoietic system
hematopoietic system phenotype ( J:221849 )
N
• tamoxifen induction of cre at 4 weeks of age
• normal myeloid cell numbers 4 months after cre induction
decreased lymphocyte cell number ( J:221849 )
• 4 months after cre induction
decreased hematopoietic stem cell number ( J:221849 )
• primitive hematopoietic stem cells is lower in bone marrow 4 months after cre induction
decreased spleen weight ( J:221849 )
• decreased spleen mass 4 months after cre induction

immune system
immune system phenotype ( J:221849 )
N
• tamoxifen induction of cre at 4 weeks of age
decreased lymphocyte cell number ( J:221849 )
• 4 months after cre induction
decreased spleen weight ( J:221849 )
• decreased spleen mass 4 months after cre induction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory