Phenotypes Associated with This Genotype

Genotype
MGI:5693263

• Allelic Composition: Taar1^{tm1(KOMP)Vlcg}/Taar1^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 10063E-C11

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to addictive substance ( J:224677 )

• homozygotes consumed 3.3 nd 6.4 fold more methamphetamine-laced water at 20mg/L and 40mg/L respectively, than did heterozgyotes or wildtype mice, and conditioned taste aversion treatment did not reduce consumption of methamphetamine-laced water by homozygotes as it did for heterozgyotes or wildtype controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:224677 )

N • homozygotes do not have a hypothermic response to methamphetamine treatment, which heterozygotes and wild-type siblings do