Phenotypes Associated with This Genotype

Genotype
MGI:5692282

• Allelic Composition: Sycp2l^tm1Jw/Sycp2l^tm1Jw
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased oocyte number ( J:225272 )

♀ • progressive reduction of primordial oocytes as compared to controls

♀ • oocyte numbers are similar to controls at 10 days of age, but drop to 20% of controls at 14 months

reproductive system

decreased oocyte number ( J:225272 )

♀ • progressive reduction of primordial oocytes as compared to controls

♀ • oocyte numbers are similar to controls at 10 days of age, but drop to 20% of controls at 14 months

decreased primary ovarian follicle number ( J:225272 )

♀ • number of primary follicles is reduced at 12 months of age as compared to controls

decreased primordial ovarian follicle number ( J:225272 )

♀ • number of primordial follicles is reduced at 2 months, 8 months and 12 months as compared to controls

decreased secondary ovarian follicle number ( J:225272 )

♀ • number of secondary follicles is reduced at 12 months of age as compared to controls

early reproductive senescence ( J:225272 )

♀ • females show accelerated reproductive aging

reduced female fertility ( J:225272 )

♀

decreased litter size ( J:225272 )

♀ • litter sizes are reduced , however number of litters is similar to controls

mortality/aging

early reproductive senescence ( J:225272 )

♀ • females show accelerated reproductive aging

endocrine/exocrine glands

decreased primary ovarian follicle number ( J:225272 )

♀ • number of primary follicles is reduced at 12 months of age as compared to controls

decreased primordial ovarian follicle number ( J:225272 )

♀ • number of primordial follicles is reduced at 2 months, 8 months and 12 months as compared to controls

decreased secondary ovarian follicle number ( J:225272 )

♀ • number of secondary follicles is reduced at 12 months of age as compared to controls