Phenotypes Associated with This Genotype

Genotype
MGI:5691394

• Allelic Composition: Hap1^tm2Xjl/Hap1^tm2Xjl; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129 * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased coping response ( J:224698 )

• mice treated with tamoxifen at early postnatal times (P1), but not at late postnatal times or as adults, show increased immobility in the forced swim test and in the tail suspension test

• mice treated with tamoxifen at P21 do not exhibit impaired hippocampal neurogenesis under normal conditions, however after repeated restraint stress, these mice show an increase in immobility compared to non-stressed mutants and stressed controls

decreased locomotor activity ( J:224698 )

• mice treated with tamoxifen at an early age exhibit lower locomotor activity as adults

nervous system

impaired neuron differentiation ( J:224698 )

• mice treated with tamoxifen at P1 show impaired neuronal differentiation in the hippocampus as indicated by a lower ratio of NeuN+/BrdU+ cells than in controls and a higher ratio of GFAP+/BrdU+ cells among BrdU+ cells

abnormal neuron proliferation ( J:224698 )

• a decrease in proliferating cells is seen in the hippocampal dentate gyrus when mice are treated with tamoxifen at P1, but not when mice are treated with tamoxifen at P21

cellular

impaired neuron differentiation ( J:224698 )

• mice treated with tamoxifen at P1 show impaired neuronal differentiation in the hippocampus as indicated by a lower ratio of NeuN+/BrdU+ cells than in controls and a higher ratio of GFAP+/BrdU+ cells among BrdU+ cells

abnormal neuron proliferation ( J:224698 )

• a decrease in proliferating cells is seen in the hippocampal dentate gyrus when mice are treated with tamoxifen at P1, but not when mice are treated with tamoxifen at P21

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
melancholic depression		DOID:1595	OMIM:608516	J:224698