Analysis Tools
immune system
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• mice administered doxycycline (Dox) exhibit an increase in IFN-gamma production in the lungs
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• mice treated with Dox show pulmonary inflammation, with infiltration of mononuclear cells in the alveolar wall and general interstitium, indicating interstitial pneumonia
• however, mice treated with Dox do not exhibit emphysema, swelled alveolar macrophages, hyaline membranes, or proteinaceous debris, and show no evidence of increased lung volumes or cardiomegaly
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respiratory system
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• mice treated with Dox show pulmonary inflammation, with infiltration of mononuclear cells in the alveolar wall and general interstitium, indicating interstitial pneumonia
• however, mice treated with Dox do not exhibit emphysema, swelled alveolar macrophages, hyaline membranes, or proteinaceous debris, and show no evidence of increased lung volumes or cardiomegaly
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• mean alveolar chord length is lower than in wild-type mice
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