About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5688487
Allelic
Composition		 Wdr1tm1.1Zzy/Wdr1tm1.1Zzy
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Wdr1tm1.1Zzy mutation (0 available); any Wdr1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:211364 )
• when treated with tamoxifen at 2 months of age, mice begin to die at 56 days after the first tamoxifen injection, and none survive past 104 days

cellular
abnormal myocardial fiber myofibril morphology ( J:211364 )
• F-actin accumulations are observed within myofibrils at 1 month after the first tamoxifen injection

cardiovascular system
abnormal myocardial fiber myofibril morphology ( J:211364 )
• F-actin accumulations are observed within myofibrils at 1 month after the first tamoxifen injection
increased myocardial fiber size ( J:211364 )
• cardiomyocyte size is increased at 1 month after the first tamoxifen injection
increased heart weight ( J:211364 )
• in male mice, the heart weight/body weight ratio begins to increase at 1 month after the first tamoxifen injection
• however, no significant changes are observed in tamoxifen-treated female mice
cardiac hypertrophy ( J:211364 )
• tamoxifen-treated mice exhibit a milder heart hypertrophy relative to that observed in mice that are homozygous for Wdr1tm1.1Zzy and hemizygous for Tg(Myhc-cre)1Xya

muscle
abnormal myocardial fiber myofibril morphology ( J:211364 )
• F-actin accumulations are observed within myofibrils at 1 month after the first tamoxifen injection
increased myocardial fiber size ( J:211364 )
• cardiomyocyte size is increased at 1 month after the first tamoxifen injection

growth/size/body
increased heart weight ( J:211364 )
• in male mice, the heart weight/body weight ratio begins to increase at 1 month after the first tamoxifen injection
• however, no significant changes are observed in tamoxifen-treated female mice
cardiac hypertrophy ( J:211364 )
• tamoxifen-treated mice exhibit a milder heart hypertrophy relative to that observed in mice that are homozygous for Wdr1tm1.1Zzy and hemizygous for Tg(Myhc-cre)1Xya

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory