Phenotypes Associated with This Genotype

Genotype
MGI:5662406

• Allelic Composition: Mirc1^tm3.1Aven/Mirc1^tm3.1Aven
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased B cell apoptosis ( J:223213 )

• increase in fraction of apoptotic pre-B cells

growth/size/body

decreased body weight ( J:223213 )

• 4-5 week old mice weigh 52% less than controls

hematopoietic system

increased B cell apoptosis ( J:223213 )

• increase in fraction of apoptotic pre-B cells

decreased pro-B cell number ( J:223213 )

decreased B cell number ( J:223213 )

• decrease in total splenic B cells

• decrease in ratio of splenic B cells to T cells and myeloid cells

decreased pre-B cell number ( J:223213 )

• decrease in percentage of pre-B cells in bone marrow

• reduction in pre-B cell numbers

decreased alpha-beta T cell number ( J:223213 )

• decrease in total splenic T cells

decreased myeloid cell number ( J:223213 )

• decrease in total splenic myeloid cell (CD11b+) number

small spleen ( J:223213 )

• reduced spleen size as compared to controls

immune system

increased B cell apoptosis ( J:223213 )

• increase in fraction of apoptotic pre-B cells

decreased pro-B cell number ( J:223213 )

decreased B cell number ( J:223213 )

• decrease in total splenic B cells

• decrease in ratio of splenic B cells to T cells and myeloid cells

decreased pre-B cell number ( J:223213 )

• decrease in percentage of pre-B cells in bone marrow

• reduction in pre-B cell numbers

decreased alpha-beta T cell number ( J:223213 )

• decrease in total splenic T cells

small spleen ( J:223213 )

• reduced spleen size as compared to controls