Phenotypes Associated with This Genotype

Genotype
MGI:5662404

• Allelic Composition: Mirc1^tm3.1Aven/Mirc1^tm3.1Aven
• Genetic Background: B6.Cg-Mirc1^tm3.1Aven

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal rostral-caudal axis patterning ( J:223213 )

limbs/digits/tail

fused carpal bones ( J:223213 )

• 21% of mice exhibit fusion of the proximal carpal bones

brachyphalangia ( J:223213 )

• the fifth mesophalanx of the forelimb is shortened as compared to controls and heterozygotes

mortality/aging

perinatal lethality, incomplete penetrance ( J:223213 )

• heterozygote x heterozygote matings produce 3% homozygotes rather than the expected 25%

skeleton

fused carpal bones ( J:223213 )

• 21% of mice exhibit fusion of the proximal carpal bones

brachyphalangia ( J:223213 )

• the fifth mesophalanx of the forelimb is shortened as compared to controls and heterozygotes

vertebral fusion ( J:223213 )

• 57% of mice exhibit vertebral fusion

vertebral transformation ( J:223213 )

thoracic vertebral transformation ( J:223213 )

• all mice exhibit transformation of vertebra 14 (T7 to T8)

• all mice exhibit transformation of vertebra 20 (T13 to L1a)

lumbar vertebral transformation ( J:223213 )

• all mice exhibit transformation of vertebra 26 (L6 to S1)

delayed bone ossification ( J:223213 )