Phenotypes Associated with This Genotype

Genotype
MGI:5662109

• Allelic Composition: Noc2l^tm1.1Arte/Noc2l^tm1.1Arte; Tg(CD2-icre)4Kio/0
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased thymocyte apoptosis ( J:216490 )

• increased apoptosis in DN3 thymocytes

abnormal T cell proliferation ( J:216490 )

• retention of the DN3 cell population indicating a block between the DN3 and DN4 stages of development

abnormal thymus morphology ( J:216490 )

• lack a distinct cortex-medulla compartmentalization

abnormal thymus cell ratio ( J:216490 )

• approximately 98% of cells recovered from the thymi are double negative

small thymus ( J:216490 )

• at 5-6 weeks of age

thymus hypoplasia ( J:216490 )

• dramatic reduction in cellularity at 5-6 weeks of age

decreased DN3 thymocyte number ( J:216490 )

• decrease in the number of DN3L (larger cycling) cells with a preservation of the DN3E (small, resting G1) population

decreased DN4 thymocyte number ( J:216490 )

• absent

abnormal thymus involution ( J:216490 )

• severe early involution is seen at 5-6 weeks of age

abnormal B cell morphology ( J:216490 )

decreased immature B cell number ( J:216490 )

• dramatic decrease in B220+IgM+ immature B cells in the bone marrow

decreased pro-B cell number ( J:216490 )

• developmental block between very early pro-B cells (B220+CD43+CD19-) and later pro-B (B220+CD43+CD19+) stage

decreased mature B cell number ( J:216490 )

• decrease in B220+IgM+ mature B cells

decreased pre-B cell number ( J:216490 )

• significant decrease in the B220+CD43- pre-B population

abnormal T cell morphology ( J:216490 )

decreased double-positive T cell number ( J:216490 )

• almost a complete absence of double positive T cells in the thymus

arrested T cell differentiation ( J:216490 )

• retention of the DN3 cell population indicating a block between the DN3 and DN4 stages of development

decreased alpha-beta T cell number ( J:216490 )

• decrease in the number of TCR-Beta producing cells

• however, the gamma-delta cell population is preserved

absent T cells ( J:216490 )

• absence of mature splenic T cells at P5

decreased single-positive T cell number ( J:216490 )

• decrease in the number of single positive CD4+ and CD8+ cells

spleen hypoplasia ( J:216490 )

• decrease in T cells and B220+IgM+ mature B cells

endocrine/exocrine glands

increased thymocyte apoptosis ( J:216490 )

• increased apoptosis in DN3 thymocytes

abnormal thymus morphology ( J:216490 )

• lack a distinct cortex-medulla compartmentalization

abnormal thymus cell ratio ( J:216490 )

• approximately 98% of cells recovered from the thymi are double negative

small thymus ( J:216490 )

• at 5-6 weeks of age

thymus hypoplasia ( J:216490 )

• dramatic reduction in cellularity at 5-6 weeks of age

decreased DN3 thymocyte number ( J:216490 )

• decrease in the number of DN3L (larger cycling) cells with a preservation of the DN3E (small, resting G1) population

decreased DN4 thymocyte number ( J:216490 )

• absent

abnormal thymus involution ( J:216490 )

• severe early involution is seen at 5-6 weeks of age

immune system

increased thymocyte apoptosis ( J:216490 )

• increased apoptosis in DN3 thymocytes

abnormal T cell proliferation ( J:216490 )

• retention of the DN3 cell population indicating a block between the DN3 and DN4 stages of development

abnormal thymus morphology ( J:216490 )

• lack a distinct cortex-medulla compartmentalization

abnormal thymus cell ratio ( J:216490 )

• approximately 98% of cells recovered from the thymi are double negative

small thymus ( J:216490 )

• at 5-6 weeks of age

thymus hypoplasia ( J:216490 )

• dramatic reduction in cellularity at 5-6 weeks of age

decreased DN3 thymocyte number ( J:216490 )

• decrease in the number of DN3L (larger cycling) cells with a preservation of the DN3E (small, resting G1) population

decreased DN4 thymocyte number ( J:216490 )

• absent

abnormal thymus involution ( J:216490 )

• severe early involution is seen at 5-6 weeks of age

abnormal B cell morphology ( J:216490 )

decreased immature B cell number ( J:216490 )

• dramatic decrease in B220+IgM+ immature B cells in the bone marrow

decreased pro-B cell number ( J:216490 )

• developmental block between very early pro-B cells (B220+CD43+CD19-) and later pro-B (B220+CD43+CD19+) stage

decreased mature B cell number ( J:216490 )

• decrease in B220+IgM+ mature B cells

decreased pre-B cell number ( J:216490 )

• significant decrease in the B220+CD43- pre-B population

abnormal T cell morphology ( J:216490 )

decreased double-positive T cell number ( J:216490 )

• almost a complete absence of double positive T cells in the thymus

arrested T cell differentiation ( J:216490 )

• retention of the DN3 cell population indicating a block between the DN3 and DN4 stages of development

decreased alpha-beta T cell number ( J:216490 )

• decrease in the number of TCR-Beta producing cells

• however, the gamma-delta cell population is preserved

absent T cells ( J:216490 )

• absence of mature splenic T cells at P5

decreased single-positive T cell number ( J:216490 )

• decrease in the number of single positive CD4+ and CD8+ cells

spleen hypoplasia ( J:216490 )

• decrease in T cells and B220+IgM+ mature B cells

cellular

abnormal cell cycle ( J:216490 )

• DN3 thymocytes show a block at the G1/S phase of the cell cycle

increased thymocyte apoptosis ( J:216490 )

• increased apoptosis in DN3 thymocytes

abnormal T cell proliferation ( J:216490 )

• retention of the DN3 cell population indicating a block between the DN3 and DN4 stages of development