Phenotypes Associated with This Genotype

Genotype
MGI:5661728

• Allelic Composition: Mtdh^Gt(XB780)Byg/Mtdh^Gt(XB780)Byg; Tg(MMTVneu)202Mul/0
• Genetic Background: FVB.Cg-Mtdh^Gt(XB780)Byg Tg(MMTVneu)202Mul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:214244 )

• by 300 days of age only 60% of mice develop tumors while almost all transgenic mice wild-type for Mtdh have tumors by this age

• by 18 months of age, 30% of mice are tumor free

decreased metastatic potential ( J:214244 )

• lung metastasis are severely reduced

increased tumor latency ( J:214244 )

• by 300 days of age only 60% of mice develop tumors while almost all transgenic mice wild-type for Mtdh have tumors by this age

• by 18 months of age, 30% of mice are tumor free

integument

decreased mammary gland tumor incidence ( J:214244 )

• by 300 days of age only 60% of mice develop tumors while almost all transgenic mice wild-type for Mtdh have tumors by this age

• by 18 months of age, 30% of mice are tumor free

mammary gland hyperplasia ( J:214244 )

• only 20% of mice are mildly hyperplastic while 100% of transgenic mice wild-type for Mtdh display hyperplasia at 6 months of age

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:214244 )

• by 300 days of age only 60% of mice develop tumors while almost all transgenic mice wild-type for Mtdh have tumors by this age

• by 18 months of age, 30% of mice are tumor free

mammary gland hyperplasia ( J:214244 )

• only 20% of mice are mildly hyperplastic while 100% of transgenic mice wild-type for Mtdh display hyperplasia at 6 months of age