Phenotypes Associated with This Genotype

Genotype
MGI:5661526

• Allelic Composition: Mus81^tm1Esse/Mus81⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta morphology ( J:222498 )

• an increase in matrix metalloproteinases activation is seen in both the thoracic aorta and abdominal aorta

abnormal aorta tunica media morphology ( J:222498 )

• aortas show increased medial thickness

abnormal aorta elastic tissue morphology ( J:222498 )

• aortas show signs of elastin breakage and increased deposition of amorphous cell material between the elastin layers

immune system

increased inflammatory response ( J:222498 )

• mice treated with LPS to mimic bacterial infection exhibit increased and prolonged inflammatory response compared to wild-type mice, showing a greater influx of macrophages, dendritic cells, T-cells, and granulocytes

respiratory system

abnormal lung morphology ( J:222498 )

• adult, but not neonatal, lungs show interruptions in the elastin layers

• graded increase in neutrophil elastase activity in the lungs

• an increase in matrix metalloproteinases activation is seen in the lungs

• however, inflammation in the lungs is not seen

overexpanded pulmonary alveolus ( J:222498 )

• alveolar airspace enlargement in adult lungs

emphysema ( J:222498 )

• mice acquire emphysematous changes with age