Phenotypes Associated with This Genotype

Genotype
MGI:5661496

• Allelic Composition: Tg(LCKprBCL2)36Sjk/0
• Genetic Background: involves: C57BL/6 * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte apoptosis ( J:217939 )

• superantigen negative selection is defective, with mice showing increased proportions of Vbeta5, Vbeta6, and Vbeta11 expressing SP thymocytes indicating enhanced rescue of thymocytes from negative selection

abnormal T cell clonal deletion ( J:217939 )

• superantigen negative selection is defective, with mice showing increased proportions of Vbeta5, Vbeta6, and Vbeta11 expressing SP thymocytes indicating impaired clonal deletion

hematopoietic system

decreased thymocyte apoptosis ( J:217939 )

• superantigen negative selection is defective, with mice showing increased proportions of Vbeta5, Vbeta6, and Vbeta11 expressing SP thymocytes indicating enhanced rescue of thymocytes from negative selection

abnormal T cell clonal deletion ( J:217939 )

• superantigen negative selection is defective, with mice showing increased proportions of Vbeta5, Vbeta6, and Vbeta11 expressing SP thymocytes indicating impaired clonal deletion

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:217939 )

• superantigen negative selection is defective, with mice showing increased proportions of Vbeta5, Vbeta6, and Vbeta11 expressing SP thymocytes indicating enhanced rescue of thymocytes from negative selection

cellular

decreased thymocyte apoptosis ( J:217939 )

• superantigen negative selection is defective, with mice showing increased proportions of Vbeta5, Vbeta6, and Vbeta11 expressing SP thymocytes indicating enhanced rescue of thymocytes from negative selection