Phenotypes Associated with This Genotype

Genotype
MGI:5661489

• Allelic Composition: Tg(LCKprBCL2)36Sjk/0; Tg(TcraH-Y,TcrbH-Y)71Vbo/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocytes are protected from apoptosis induced by an HY TCR-specific peptide indicating impaired clonal deletion

hematopoietic system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocytes are protected from apoptosis induced by an HY TCR-specific peptide indicating impaired clonal deletion

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis

cellular

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to an HY TCR-specific peptide compared to controls which show massive apoptosis